![]() ![]() ![]() “Although mitochondrial defects do impair the ability of cells to produce energy, energy deficiency may not be the primary disease initiator. In their search for new treatments for mitochondrial diseases, researchers should focus on hypermetabolism, Picard says. Improving organismal efficiency, which would lower energy use in the cells and improve fatigue and other symptoms, may partially explain the health benefits of exercise in patients with mitochondrial diseases and otherwise healthy people. An individual who runs, for example, uses less energy to sustain basic bodily processes than someone who is not physically active.” “That may seem counterintuitive, since if you’re more active, you’re going to expend more energy and possibly make your symptoms worse,” Sturm says. “But exercise is known to increase the efficiency of an organism. The study doesn’t point to any new remedies for patients with mitochondrial diseases, which are currently not treatable, but it does reinforce the current recommendations for patients to move more. We likely see the same dynamic as people age and their vitality diminishes,” Picard says. “To make up for the extra energy use in your cells, your body ‘tells’ you not to overexert yourself, to conserve energy. This hypermetabolic state could explain why people with mitochondrial diseases experience fatigue and exercise intolerance, among other symptoms. Illustration provided by Martin Picard, Columbia University Irving Medical Center. Hypermetabolism also may be a key reason why most cells deteriorate as everyone gets older. Though that helps short-term survival, it comes at a high cost: a dramatic increase in the rate at which the cells age. Mitochondrial defects caused by rare genetic mutations cause human cells to increase their metabolism. “When cells expend more energy to make proteins and other substances essential for short-term survival, they’re likely stealing resources from processes that ensure long-term survival, like maintaining telomeres,” says Gabriel Sturm, a graduate student and lead author on this study. The net effect accelerates biological aging. Moreover, re-analyzing data from hundreds of patients with different mitochondrial diseases showed that mitochondrial defects also increase the energetic cost of living at the whole-body level.Īlthough this energy boost keeps cells running, it also degrades the cell’s telomeres (caps that protect the ends of our chromosomes) and activates stress responses and inflammation. However, by analyzing metabolic activity and energy consumption in cells from patients with mitochondrial diseases, the researchers found that cells with impaired mitochondria double their energy expenditure. It was generally assumed that mitochondrial defects (which impair the conversion of food sources into usable energy) would force cells to slow their metabolic rate in an effort to conserve energy. “In addition, hypermetabolism may be a key reason why most cells deteriorate as we get older.” Hypermetabolic cells age faster “The findings were made in cells from patients with rare mitochondrial diseases, yet they may also have relevance for other conditions that affect mitochondria, including neurodegenerative diseases, inflammatory conditions, and infections,” says principal investigator Martin Picard, PhD, associate professor of behavioral medicine (in psychiatry and neurology) at Columbia University Vagelos College of Physicians and Surgeons. While this adaptation-called hypermetabolism-enhances the cells’ short-term survival, it comes at a high cost: a dramatic increase in the rate at which the cells age. 12 in Communications Biology, a team led by Columbia University researchers has discovered that human cells with impaired mitochondria respond by kicking into higher gear and expending more energy. Though that idea is not new, direct evidence in human cells had been lacking. ![]() Why do cells, and by extension humans, age? The answer may have a lot to do with mitochondria, the organelles that supply cells with energy. ![]()
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